Alzheimer's Disease: A Century of Scientific and Clinical Research

Front Cover
George Perry
IOS Press, 2006 - Medical - 456 pages
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This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimers original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today.

To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

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IT IS FOUR YEARS SHORT OF THE MOST INTERESTING AD RESEARCH AND CLINICAL TRIALS

Contents

List of contributors
1
Years of Alzheimers disease 19062006
15
A surprise in retrospect
29
40 Years of learning
45
Clinicopathological analysis of dementia disorders in the elderly An update
61
The roles of plasticity and columnar organization
79
Neocortex and hippocampus
101
My own experience in early research on Alzheimer disease
117
Insights and perspectives
243
Progress from Alzheimers tangles to pathological tau points towards more effective therapies now
257
The last 12 years
271
Aluminium and Alzheimers disease a personal perspective after 25 years
291
How rust became the fuss
305
Segregation of a missense mutation in the amyloid ▀protein precursor gene with familial
341
On the discovery of the genetic association of Apolipoprotein E genotypes and common lateonset
361
and Bernardino Ghetti
374

The scarlet pimpernel
129
The amyloid cascade hypothesis An update and reappraisal
151
Tau protein the main component of paired helical filaments
171
The natural and molecular history of Alzheimers disease
187
Neurofibrillary tanglespaired helical filaments 198183
209
Genetics and pathology of alphasecretase site A▀PP mutations in understanding
389
Twodecades of progress
409
From in vitro amyloid immunomodulation to in vivo vaccination
433
The bridge from the cholinergic basal forebrain to cognitive science and bioethics
447
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