Alzheimer's Disease: A Century of Scientific and Clinical ResearchThis publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer's original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us. |
Contents
List of contributors | 1 |
Years of Alzheimers disease 19062006 | 15 |
A surprise in retrospect 29 | 29 |
40 Years of learning | 45 |
Clinicopathological analysis of dementia disorders in the elderly An update | 61 |
The roles of plasticity and columnar organization | 79 |
Neocortex and hippocampus | 101 |
My own experience in early research on Alzheimer disease | 117 |
A personal account | 251 |
Progress from Alzheimers tangles to pathological tau points towards more effective therapies | 257 |
A long trek down the pathways of cell death in Alzheimers disease | 265 |
The last 12 years | 271 |
Genes to neurodegeneration in Alzheimers disease | 277 |
Aluminium and Alzheimers disease a personal perspective after 25 years | 291 |
How rust became the fuss | 305 |
Segregation of a missense mutation in the amyloid ẞprotein precursor gene with familial | 341 |
Transgenic approaches and Alzheimers disease | 133 |
The amyloid cascade hypothesis An update and reappraisal | 151 |
Tau protein the main component of paired helical filaments | 171 |
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimers disease | 177 |
Tau protein the paired helical filament and Alzheimers disease | 195 |
Neurofibrillary tanglespaired helical filaments 198183 | 209 |
Insights and perspectives | 243 |
On the discovery of the genetic association of Apolipoprotein E genotypes and common lateonset | 361 |
and Bernardino Ghetti | 374 |
Genetics and pathology of alphasecretase site AẞPP mutations in understanding | 389 |
Twodecades of progress | 409 |
From in vitro amyloid immunomodulation to in vivo vaccination | 433 |
The bridge from the cholinergic basal forebrain to cognitive science and bioethics | 447 |
Other editions - View all
Alzheimer's Disease: A Century of Scientific and Clinical Research G. Perry,J. Avila,J. Kinoshita Limited preview - 2006 |
Common terms and phrases
abnormal Acad Sci USA Acta Neuropathol activity aging Alzheimer disease amyloid beta amyloid deposition amyloid plaques amyloid precursor protein amyloid-ẞ antibodies areas associated AẞPP axonal Biochem Biol Chem Braak Brain Res cells cerebral cortex cholinergic chromosome clinical clones cognitive cortical D.J. Selkoe degeneration disorders familial Alzheimer's disease fibrils formation frontotemporal dementia genetic Ghetti Glenner Goedert Grundke-Iqbal H.M. Wisniewski hippocampal human hyperphosphorylation IOS Press Iqbal kinase lesions Lewy bodies loss lysosomal Masliah microscopy microtubule microtubule-associated protein molecular mouse model mutations Natl Acad Sci neocortex neuritic Neurobiol neurodegenerative neurofibrillary tangles neurofilament Neurology neurons neuropathology Neurosci normal oxidative paired helical filaments Pathol pathway patients peptide Perry phosphorylation presenilin Proc Natl Acad protein tau R.D. Terry region role Science senile dementia senile plaques sequence soluble studies synaptic tacrine tau isoforms tau pathology tau protein tauopathies tion tissue transgenic transgenic mice vascular vitro vivo