Alzheimer's Disease: A Century of Scientific and Clinical ResearchG. Perry, J. Avila, J. Kinoshita This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us. |
Contents
A century of scientific and clinical research | 1 |
Historical Perspective | 3 |
The importance of context | 5 |
Neuropathology | 27 |
Synaptic Changes | 77 |
Amyloid | 121 |
Tau | 169 |
Disease Mechanisms | 263 |
Genetics | 327 |
Diagnosis and Treatment | 399 |
455 | |
Other editions - View all
Alzheimer's Disease: A Century of Scientific and Clinical Research George Perry Limited preview - 2006 |
Common terms and phrases
abnormal Acad Sci USA Acta Neuropathol activity aging Alzheimer disease Alzheimer’s disease amyloid beta amyloid deposition amyloid plaques amyloid precursor protein antibodies areas associated axonal Biochem Biol Braak Brain Res cells cerebral cortex Chem cholinergic chromosome clinical clones cognitive cortical D.J. Selkoe degeneration disorders familial Alzheimer’s disease fibrils formation frontotemporal dementia genetic Ghetti Glenner Goedert Grundke-Iqbal H.M. Wisniewski hippocampal hyperphosphorylation impairment IOS Press Iqbal kinase lesions Lewy bodies loss lysosomal Masliah microscopy microtubule microtubule-associated protein molecular mouse model mutations Natl Acad Sci neocortex neuritic Neurobiol neurodegenerative neurofibrillary changes neurofibrillary tangles neurofilament Neurology neurons neuropathology Neurosci normal paired helical filaments Pathol pathway patients peptide phosphorylation presenilin Proc Natl Acad protein tau R.D. Terry region role Science senile dementia senile plaques sequence soluble studies synaptic tacrine tau isoforms tau pathology tau protein tauopathies tion tissue transgenic transgenic mice vascular vitro