Landmark Papers in Neurosurgery
Reuben Johnson, Alexander Green
OUP Oxford, Aug 12, 2010 - Medical - 283 pages
Evidence-based medicine is a concept that has come to the fore in the past few years. Clinicians are increasingly encouraged to practise patient management based on available evidence in the scientific literature. For example, new pharmacological therapies are only used when large randomized trials have 'proven' that a particular drug is better than existing ones. This is also the case in surgical specialties, although surgery has traditionally seen a lack of use of this information, with individual surgeon's preferences being most influential in treatment choices. However, more recently, there has been a large expansion of trials and studies aimed at providing surgeons with information to guide their choices using firm evidence. This book provides a detailed summary of the most important trials and studies in neurosurgery, allowing the reader to rapidly extract key results. Each chapter is written by a prominent international neurosurgeon in that particular field, making this book essential reading for all neurosurgeons and trainees in the field.
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acute spinal cord analysis aneurysms artery assessed AVMs benefit brain metastases carmustine cerebral Class of evidence Critique decompressive craniectomy Details of study disability effects efficacy epilepsy evaluating evidence I Randomization extent of resection follow-up Glasgow Outcome Scale head-injured patients hypothermia improvement included Inclusion criteria infarction intention-to-treat intracranial pressure Jennett Lancet landmark long-term low-grade gliomas malignant glioma mannitol measures Primary endpoints metastases mmHg months mortality multi-centre Neurol neurological Neurosurg Neurosurgery nimodipine Number of centres Number of patients Outcome measures Primary pain Parkinson’s disease Patchell placebo pravastatin Primary outcomes radiotherapy randomised randomized controlled trial randomized trial recurrence reduce references Main study Related references risk role score Secondary endpoints Secondary outcomes seizures shunt spinal cord injury Spine Statistical significance stenosis steroids stimulation Stratification Study design Study references Main subarachnoid haemorrhage subdural haematomas surgery surgical survival temozolomide therapy traumatic brain injury treatment vasospasm WBRT