The Mouse in Biomedical Research: History, Wild Mice, and Genetics

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Elsevier, Dec 4, 2006 - Science - 352 pages
History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
 

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Contents

One Hundred Years of Genetics and Biology
1
Chapter 2 Systematics of the genus Mus
13
Chapter 3 The Secret World of Wild Mice
25
Considerations Genetic Fundamentals Genetic Background and Strain Types
53
an Abbreviated Guide
79
Chapter 6 The Mouse Genome
99
Chapter 7 Gene Mapping
115
Chapter 8 Genetic Monitoring
135
Chapter 11 Gamete and Embryo Manipulation
211
Chapter 12 Chemical Mutagenesis in Mice
225
Chapter 13 GeneSpecific Mutagenesis
261
Chapter 14 Gene Transfer Studies Using Mouse Models
267
Chapter 15 Mouse and Human Pluripotent Stem Cells
281
Pharmacology Pharmacogenetics and Pharmacogenomics
289
Index
321
Colour Plates
328

Chapter 9 Cytogenetics
145
Research Techniques and a Comparison of Embryonic Development between Mouse and Man
165

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About the author (2006)

James G. Fox, DVM, MS, DACLAM, is a Professor and Director of the Division of Comparative Medicine and a Professor in the Division of Biological Engineering at the Massachusetts Institute of Technology. He is also an Adjunct Professor at Tufts University School of Veterinary Medicine and the University of Pennsylvania, School of Veterinary Medicine. He is a Diplomate and a past president of the American College of Laboratory Animal Medicine, past president of the Massachusetts Society of Medical Research, past chairman of AAALAC Council, and past chairman of the NCCR/NIH Comparative Medicine Study Section. He also is an elected fellow of the Infectious Disease Society of America. Professor Fox is the author of over 490 articles, 80 chapters, 3 patents and has edited and authored 13 texts in the field of in vivo model development and comparative medicine.

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