Alzheimer's Disease: A Century of Scientific and Clinical Research

Front Cover
IOS Press, 2006 - Medical - 456 pages
This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer's original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.
 

Contents

List of contributors
1
Years of Alzheimers disease 19062006
15
A surprise in retrospect 29
29
40 Years of learning
45
Clinicopathological analysis of dementia disorders in the elderly An update
61
The roles of plasticity and columnar organization
79
Neocortex and hippocampus
101
My own experience in early research on Alzheimer disease
117
A personal account
251
Progress from Alzheimers tangles to pathological tau points towards more effective therapies
257
A long trek down the pathways of cell death in Alzheimers disease
265
The last 12 years
271
Genes to neurodegeneration in Alzheimers disease
277
Aluminium and Alzheimers disease a personal perspective after 25 years
291
How rust became the fuss
305
Segregation of a missense mutation in the amyloid ẞprotein precursor gene with familial
341

Transgenic approaches and Alzheimers disease
133
The amyloid cascade hypothesis An update and reappraisal
151
Tau protein the main component of paired helical filaments
171
Immunological demonstration of tau protein in neurofibrillary tangles of Alzheimers disease
177
Tau protein the paired helical filament and Alzheimers disease
195
Neurofibrillary tanglespaired helical filaments 198183
209
Insights and perspectives
243
On the discovery of the genetic association of Apolipoprotein E genotypes and common lateonset
361
and Bernardino Ghetti
374
Genetics and pathology of alphasecretase site AẞPP mutations in understanding
389
Twodecades of progress
409
From in vitro amyloid immunomodulation to in vivo vaccination
433
The bridge from the cholinergic basal forebrain to cognitive science and bioethics
447
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