Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2

Front Cover

BEIR VII develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation. It is among the first reports of its kind to include detailed estimates for cancer incidence in addition to cancer mortality. In general, BEIR VII supports previously reported risk estimates for cancer and leukemia, but the availability of new and more extensive data have strengthened confidence in these estimates. A comprehensive review of available biological and biophysical data supports a "linear-no-threshold" (LNT) risk modelā€"that the risk of cancer proceeds in a linear fashion at lower doses without a threshold and that the smallest dose has the potential to cause a small increase in risk to humans. The report is from the Board on Radiation Research Effects that is now part of the newly formed Nuclear and Radiation Studies Board.

 

Contents

Public Summary
1
Executive Summary
11
1 Background Information
19
2 Molecular and Cellular Responses to Ionizing Radiation
43
Mechanisms Quantitative Experimental Studies and the Role of Genetic Factors
65
4 Heritable Genetic Effects of Radiation in Human Populations
91
5 Background for Epidemiologic Methods
132
6 Atomic Bomb Survivor Studies
141
12 Estimating Cancer Risk
267
13 Summary and Research Needs
313
Appendixes
325
A Basic Biological and Genetic Concepts
327
Dose Response Studies with Physicians per 100000 Population
329
C Issues Raised by the Institute for Energy and Environment Research IEER
330
D Hormesis
332
E FifteenCountry Workers Study
336

7 Medical Radiation Studies
155
8 Occupational Radiation Studies
189
9 Environmental Radiation Studies
207
10 Integration of Biology and Epidemiology
239
11 Risk Assessment Models and Methods
259
References
337
Glossary
373
Committee Biographies
379
Index
385
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