Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII _ Phase 2This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called _late_ effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation. |
Contents
1 | |
Executive Summary | 11 |
1 Background Information | 19 |
2 Molecular and Cellular Responses to Ionizing Radiation | 43 |
Mechanisms Quantitative Experimental Studies and the Role of Genetic Factors | 65 |
4 Heritable Genetic Effects of Radiation in Human Populations | 91 |
5 Background for Epidemiologic Methods | 132 |
6 Atomic Bomb Survivor Studies | 141 |
12 Estimating Cancer Risk | 267 |
13 Summary and Research Needs | 313 |
Appendixes | 325 |
A Basic Biological and Genetic Concepts | 327 |
Dose Response Studies with Physicians per 100000 Population | 329 |
C Issues Raised by the Institute for Energy and Environment Research IEER | 330 |
D Hormesis | 332 |
E FifteenCountry Workers Study | 336 |
Other editions - View all
Common terms and phrases
A-bomb absolute risk absorbed dose acute age at exposure analyses associated atomic bomb survivors attained age autosomal dominant average BEIR VII Belarus breast cancer bystander effect cancer incidence cancer mortality cancer risk case-control study cells cellular Chernobyl accident chronic cohort studies colleagues committee committee’s DDREF DNA damage dose-rate dose-response relationship dosimetry DSBs EAR models ERR/Sv esti evaluated evidence excess expo exposed factors fluoroscopy follow-up frequency genes genomic instability human ICRP incidence data included induced ionizing radiation irradiation leukemia lifetime risk linear loci low-dose low-LET radiation LSS cohort lung cancer lymphoma mice minisatellite molecular mortality data mouse mutation rate nuclear parameters patients Preston Radiat Res radiation dose radiation exposure radiation risk radiation-induced radiotherapy range relative risk repair risk estimates risk transport Sellafield site-specific solid cancers specific spontaneous statistically Table telomere thyroid cancer tion tumorigenesis tumors uncertainty UNSCEAR workers X-rays