The Mouse in Biomedical Research: History, Wild Mice, and GeneticsHistory, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research. |
Contents
| 1 | |
| 13 | |
Chapter 3 The Secret World of Wild Mice | 25 |
Considerations Genetic Fundamentals Genetic Background and Strain Types | 53 |
an Abbreviated Guide | 79 |
Chapter 6 The Mouse Genome | 99 |
Chapter 7 Gene Mapping | 115 |
Chapter 8 Genetic Monitoring | 135 |
Chapter 11 Gamete and Embryo Manipulation | 211 |
Chapter 12 Chemical Mutagenesis in Mice | 225 |
Chapter 13 GeneSpecific Mutagenesis | 261 |
Chapter 14 Gene Transfer Studies Using Mouse Models | 267 |
Chapter 15 Mouse and Human Pluripotent Stem Cells | 281 |
Pharmacology Pharmacogenetics and Pharmacogenomics | 289 |
| 321 | |
Colour Plates | 328 |
Chapter 9 Cytogenetics | 145 |
Research Techniques and a Comparison of Embryonic Development between Mouse and Man | 165 |
Other editions - View all
The Mouse in Biomedical Research: History, Wild Mice, and Genetics James G. Fox No preview available - 2007 |
Common terms and phrases
Acad allele analysis animals backcross behavior biochemical Biol biology breeders breeding scheme chemical clones congenic strains cross cryopreservation database days p.c. deletions detected differentiation disease domesticus drug target embryonic stem cells embryos example F1 hybrids female function gene expression gene transfer genetic background genome genome sequence genotype germ cells heterozygotes heterozygous homozygotes homozygous house mice house mouse human hybrid identified inbred strains induced intercross Jackson Laboratory karyotype Kaufman knockout mouse laboratory mouse linkage loci locus male mammalian mapping markers mating meiotic method microinjection molecular mouse chromosomes mouse embryos mouse genome mouse strains Mus musculus mutagenesis mutagenized mutations Natl nomenclature offspring oocytes phenotype polymorphisms Proc produce protein receptor recessive recombinant inbred region reproductive rodents screening Singleton SNPs species sperm stage studies techniques tion tissue traits transgenic variation vectors viral virus vitro vivo wild-type